science
If one were to trust the diagrams found in introductory biology textbooks, molecular recognition would appear to be a serene, orderly, and deterministic affair. The "Lock and Key" model, proposed by Emil Fischer in 1894, depicts the protein as a rigid, Pac-Man-like entity with a mouth the active
science
In the high stakes world of modern drug discovery, finding a binding pocket on a disease causing protein is only half the battle. The real challenge and the subject of intense biophysical debate is deciding what kind of "key" should fit that lock. For most of the 20th
beginner
Water is essential for life, that’s something we all know. But beyond keeping us alive, water also shapes how molecules recognize, interact, and bind to each other. In the world of proteins and ligands, it’s far more than just a background solvent. Inside a protein’s binding pocket,
beginner
Picture a thriller where the hero tracks down the villain using perfect surveillance footage, kicks down the warehouse door, and finds nothing. The target vanished hours ago. This is exactly what happened when our docking algorithm ranked millions of "perfect" binders in an afternoon. The wet lab results?
Release
We present LiteFold DeNovo, our second flagship feature, a highly efficient structure based drug design workflow to accelerate your lead candidate research to the next level. In this blog, we will discuss the features that are available today, how to get started, and the new features that are coming very
science
Structural biology delves into fundamental biological structures such as proteins, DNA, and RNA, examining their behaviors, formations, and conformations. The integration of structural biology with AI has opened numerous avenues, including predicting 3D structures of proteins and simulating interactions, thereby advancing fields like omics biology in general and medicine 3.